Advantix® offers broad spectrum protection against fleas, ticks and mosquitoes, too. It is specifically formulated for dogs and comes in a convenient, monthly topical application that not only kills but also repels fleas, ticks and mosquitoes. K9 Advantix® II also kills ALL life stages of fleas, repels biting flies and kills lice. Advantix is a once-a-month topical application for dogs and puppies that REPELS and kills ticks, fleas, and mosquitoes. Advantix contains imidacloprid, permethrin and pyriproxyfen that work in concert to REPEL and kill parasites that can potentially transmit disease-causing organisms.